Articles

TCR-based T cell immunotherapy for AML: Multidimensional aids in optimising treatment and patient identification

BJH - volume 13, issue 4, june 2022

S. Bonte PhD, T. Kerre MD, PhD

SUMMARY

Acute myeloid leukaemia (AML) has a dismal outcome, as demonstrated by a 5-year overall survival rate of only 26%. Although a complete remission can be achieved in approximately 50% of the patients with classical chemotherapy, the chances of relapse are high. Current treatment options for relapsed or refractory AML only offer a bridge to allogeneic haematopoietic stem cell transplantation since no other curative option exists. In primary refractory patients, and patients at high risk for relapse, harnessing the power of the immune system with immunotherapy might provide a new treatment option. In this dissertation, we approached AML immunotherapy from two sides: the optimisation of TCR-based immunotherapy for AML, and of the identification of patients eligible for this type of treatment.

(BELG J HEMATOL 2022;13(4):165–7)

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O.4 An in-depth investigation of the causes of treatment failure in AML

BJH - volume 11, issue Abstract Book BHS, february 2020

S. Bonte PhD, S. Van Gassen , A. Couckuyt , V. Janda , I. Moors MD, dr. A. Delie MD, S. Kennes MD, J. Philippé MD, PhD, Y. Saeys , T. Kerre MD, PhD

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P13 In vitro generation of tumor antigen-specific T cells from patient and healthy donor stem cells

BJH - 2018, issue Abstract Book BHS, february 2018

S. Bonte PhD, S. Snauwaert MD, PhD, G. Goetgeluk , B. Vandekerckhove MD, PhD, T. Kerre MD, PhD

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O.4 In vitro generation of tumor antigen-specific T cells from patient and healthy donor stem cells

BJH - volume 8, issue Abstract Book BHS, february 2017

S. Bonte PhD, S. Snauwaert MD, PhD, G. Goetgeluk , B. Vandekerckhove MD, PhD, T. Kerre MD, PhD

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PP4.5 Functional in vitro evaluation of T cells generated from minor H antigen-TCR transduced human hematopoietic stem cells using the OP9-DL1 coculture system

BJH - volume 7, issue Abstract Book BHS, january 2016

S. Bonte PhD, S. Snauwaert MD, PhD, M. Heemskerk , B. Vandekerckhove MD, PhD, T. Kerre MD, PhD

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P2.01 Functional evaluation of T cells generated from WT1-TCR transduced human hematopoietic stem cells using the OP9-DL1 coculture system

BJH - volume 6, issue Abstract Book BHS, january 2015

S. Bonte PhD, S. Snauwaert MD, PhD, G. Goetgeluk , M.H.M. Heemskerk , H. Stauss , R. Stripecke , B. Vandekerckhove MD, PhD, T. Kerre MD, PhD

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P1.12 Chronic EBV infection resulting in a CD20 negative lymphoproliferative disorder complicated with secondary hemophagocytosis

BJH - volume 5, issue Abstract Book BHS, january 2014

P. Vlummens MD, S. Bonte PhD, V. Van Hende MD, T. Kerre MD, PhD

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