Articles

PP50 Comparison of xenogeneic graft-versus-host reactions in humanized NSG and NSG-HLA-A2/HHD mice

BJH - volume 8, issue Abstract Book BHS, february 2017

G. Ehx , G. Fransolet , L. Delens , J. Muller MSc, Y. Beguin MD, PhD, S. Humblet-Baron , M. Hannon , prof. F. Baron

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PP74 Limited impact of imatinib in a murine model of sclerodermatous chronic graft-versus-host disease

BJH - volume 8, issue Abstract Book BHS, february 2017

G. Fransolet , L. Belle , J. Somja MD, PhD, M. Binsfeld , P. Delvenne , P. Drion , M. Hannon , Y. Beguin MD, PhD, G. Ehx , prof. F. Baron

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Multipotent mesenchymal stromal cell therapy for steroid-refractory acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation

BJH - volume 7, issue 6, december 2016

S. Servais MD, PhD, C. Grégoire MD, prof. F. Baron , E. Willems MD, PhD, A. Briquet PhD, E. Baudoux MD, O. Delloye PhD, O. Giet PhD, C. Lechanteur PhD, Y. Beguin MD, PhD

Summary

Steroid-refractory acute graft-versus-host disease is a severe complication after allogeneic stem cell transplantation. So far, its treatment remains very challenging since the current therapies do not offer significant benefits. Among the most recent approaches, multipotent mesenchymal stromal cell-based therapy has attracted great interest over the past decade. Here, we briefly reviewed the current knowledges about the immunomodulatory properties of multipotent mesenchymal stromal cells as well as results of preclinical and clinical studies having assessed their efficacy to modulate steroid-refractory acute graft-versus-host disease.

(BELG J HEMATOL 2016;7(6):229–35)

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Highlights in acute leukemia

BJH - volume 7, issue 1, february 2016

prof. F. Baron

Summary

This report on the best ASH abstracts for acute leukemia will be divided into a section on acute myeloid leukemia (AML) and a second section on acute lymphoblastic leukemia (ALL).

(BELG J HEMATOL 2016; 7(1):27–30)

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PP3.1 Azacytidine prevents experimental sclerodermic chronic graft-versus-host disease

BJH - volume 7, issue Abstract Book BHS, january 2016

G. Fransolet , G. Ehx , J. Somja MD, PhD, L. Delens , M. Hannon , S. Dubois , P. Drion , J. Caers MD, PhD, S. Humblet-Baron , L. Belle , P. Delvenne , Y. Beguin MD, PhD, G. Conteduca , prof. F. Baron

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O.4 SRC kinase inhibition with saracatinib limits the development of osteolytic bone disease in multiple myeloma

BJH - volume 7, issue Abstract Book BHS, january 2016

R. Heusschen PhD, J. Muller MSc, M. Binsfeld , E. Plougonven , N. Mahli , G. Carmeliet , A. Léonard , prof. F. Baron , M. Cohen-Solal , K. Vanderkerken PhD, Y. Beguin MD, PhD, E. Menu , J. Caers MD, PhD

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P2.06 Salt but not glucocorticosteroïds enhances Th17 differentiation from naïve T cells in vitro

BJH - volume 7, issue Abstract Book BHS, january 2016

L. Delens , S. Servais MD, PhD, L. Vrancken , G. Ehx , G. Fransolet , M. Hannon , S. Dubois , C. Daulne , Y. Beguin MD, PhD, prof. F. Baron

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