Articles

Acute graft-versus-host disease: diagnosis, pathophysiology and prevention

BJH - volume 11, issue 4, june 2020

B. Vandenhove PhD student, L. Canti PhD student, H. Schoemans MD, PhD, Y. Beguin MD, PhD, F. Baron MD, PhD, E. Willems MD, PhD, C. Graux MD, PhD, T. Kerre MD, PhD, S. Servais MD, PhD

SUMMARY

Acute graft-versus-host disease (aGVHD) remains a severe complication after allogeneic stem cell transplantation (alloHCT). It is a disregulated immune process, during which the immune cells of the donor attack the healthy tissues in the immunocompromised host. Over the past two decades, progress in understanding its pathophysiology have helped redefine aGVHD reactions and clinical presentations. Typically, the disease presents with serious inflammatory lesions mainly in the skin, gut and liver. Its severity is assessed by gathering clinical signs and dysfunctions of each organ. Despite standard prophylaxis regimens, aGVHD still occurs in approximately 30–60% of transplanted patients and remains a major cause of transplant-related morbidity and mortality. Hence, there is an urgent need for optimising preventive strategies. In this review, we give insights on how to make an accurate diagnosis and scoring assessment of aGVHD, propose a short overview of the current knowledge about its immunobiology and discuss the current and developing strategies for prevention.

(BELG J HEMATOL 2020;11(4):159–173)

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PP43 Graft-versus-host disease (GVHD) of the central nervous system (CNS) after allogeneic hematopoietic cell transplantation (alloHCT): case report

BJH - 2018, issue Abstract Book BHS, february 2018

M. Pirotte , F. Forte , L. Lutteri , B. Otto , E. Willems MD, PhD, L. Belle , F. Baron MD, PhD, Y. Beguin MD, PhD, P. Maquet , O. Bodard , S. Servais MD, PhD

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Multipotent mesenchymal stromal cell therapy for steroid-refractory acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation

BJH - volume 7, issue 6, december 2016

S. Servais MD, PhD, C. Grégoire MD, F. Baron MD, PhD, E. Willems MD, PhD, A. Briquet PhD, E. Baudoux MD, O. Delloye PhD, O. Giet PhD, C. Lechanteur PhD, Y. Beguin MD, PhD

Summary

Steroid-refractory acute graft-versus-host disease is a severe complication after allogeneic stem cell transplantation. So far, its treatment remains very challenging since the current therapies do not offer significant benefits. Among the most recent approaches, multipotent mesenchymal stromal cell-based therapy has attracted great interest over the past decade. Here, we briefly reviewed the current knowledges about the immunomodulatory properties of multipotent mesenchymal stromal cells as well as results of preclinical and clinical studies having assessed their efficacy to modulate steroid-refractory acute graft-versus-host disease.

(BELG J HEMATOL 2016;7(6):229–35)

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PP2.1 Immunomodulatory effects of rapamycin in Graft versus Host Disease

BJH - volume 7, issue Abstract Book BHS, january 2016

G. Ehx , M. Hannon , S. Humblet-Baron , S. Dubois , C. Daulne , P. Drion , E. Willems MD, PhD, S. Servais MD, PhD, Y. Beguin MD, PhD, F. Baron MD, PhD

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O.4 Impact of pre-transplant infusion of antithymocyte globulin (ATG-Fresenius) on immune recovery after high intensity conditioning allogeneic stem cell transplantation

BJH - volume 6, issue Abstract Book BHS, january 2015

S. Servais MD, PhD, C. Menten , Y. Beguin MD, PhD, C. Daulne , L. Delens , E. Willems MD, PhD, M. Hannon , F. Baron MD, PhD

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P3.03 Study of immune recovery in a randomized phase II trial of sequential double autologous transplantation with unmanipulated or AC133+ PBSC in patients with multiple myeloma

BJH - volume 6, issue Abstract Book BHS, january 2015

M. Hannon , S. Servais MD, PhD, R. Schots MD, PhD, E. Castermans , L. Seidel , A. Gothot MD, PhD, E. Baudoux MD, O. Giet PhD, N. Wanten , E. Willems MD, PhD, C. Daulne , I. Van Riet PhD, Y. Beguin MD, PhD, F. Baron MD, PhD

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P3.05 Long-term safety follow-up of a randomized trial of darbepoetin alpha and intravenous iron following autologous hematopoietic cell transplantation

BJH - volume 6, issue Abstract Book BHS, january 2015

A. Jaspers MD, PhD, F. Baron MD, PhD, J. Maertens MD, PhD, B. De Prijck MD, R. Schots MD, PhD, C. Bonnet MD, PhD, K. Hafraoui , E. Willems MD, PhD, S. Servais MD, PhD, G. Fillet , Y. Beguin MD, PhD

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