BJH - volume 9, issue 4, august 2018
T. Feys MBA, MSc
EHA 2018 featured several eagerly awaited presentations on Hodgkin lymphoma. This included subgroup data of the ECHELON-1 trial in patients with high-risk features and data of a PET-based treatment de-escalation study. In non-Hodgkin lymphoma, the RELEVANCE study assessed the chemotherapy-free lenalidomide-rituximab combination as 1st line treatment for follicular lymphoma. In diffuse-large-B-cell lymphoma, updates were presented of the key studies evaluating CAR T-cell therapy and polatuzumab vedotin was found to improve the survival in relapsed/refractory patients.
(BELG J HEMATOL 2018;9(4):152–6)
Read moreBJH - volume 9, issue 3, june 2018
T. Feys MBA, MSc
OVERVIEW OF BELGIAN REIMBURSEMENT NEWS
(BELG J HEMATOL 2018;9(3):130)
Read moreBJH - volume 9, issue 1, february 2018
T. Feys MBA, MSc
There has been a long period of time without any new acute myeloid leukemia (AML) treatments. However, the tide has turned and data presented at ASH 2017 confirm that there are several promising therapies on the horizon. In fact, the FDA recently approved the FLT3 inhibitor midostaurin, the IDH2 inhibitor enasidenib and CPX-351 (liposomal daunorubicin and cytarabine) in the treatment of AML. In addition to this, promising data were presented with CAR T-cell therapy and (bispecific) antibodies, with the Bcl-2 inhibitor venetoclax and many more. In addition to this, results of a HOVON trial were presented demonstrating clinical benefit of azacitidine maintenance therapy in older AML patients and refractory anemia with excess of blasts. ASH 2017 also featured the presentation of several studies assessing the role of MRD in the setting of AML. With respect to acute lymphoblastic leukemia (ALL), the most notable presentations included the results of the GIMEMA LAL1811 study evaluating the combination of steroids and ponatinib as frontline therapy in elderly, or unfit Philadelphia chromosome positive (Ph+) ALL and the results of a study assessing the combination of bosutinib with inotuzumab ozogamicin in patients with relapsed/refractory Ph+ ALL or CML in lymphoid blast phase. In addition to this, Rambaldi et al. presented the overall survival (OS) data for adult patients with relapsed/refractory B-precursor ALL (B-ALL) who were treated with maintenance blinatumomab. We would like to acknowledge Dr. Dimitri Breems (department of hematology, ZNA Stuivenberg, Antwerp) for his help in selecting the abstracts for this summary.
(BELG J HEMATOL 2018;9(1):28–37)
Read moreBJH - volume 8, issue 5, september 2017
T. Feys MBA, MSc
From July 8–13, Berlin formed the background for the 2017 annual meeting of the International Society on Thrombosis and Haemostasis. During the congress, thousands of the world’s leading experts on thrombosis, haemostasis and vascular biology came together to present the most recent advances, exchange the latest science and discuss the newest clinical applications designed to improve patient care. In this summary, some of the key studies presented at the meeting will be discussed. For a more complete coverage of the meeting, we happily refer to the congress website: www.isth2017.org.
(BELG J HEMATOL 2017;8(5):203–7)
Read moreBJH - volume 8, issue 4, august 2017
T. Feys MBA, MSc
Practice changing novelties in the treatment of classical Hodgkin lymphoma (cHL) were scarce at EHA 2017. This summary will discuss three abstracts presented during an oral session dedicated to clinical findings in Hodgkin (HL) and indolent Non-Hodgkin Lymphoma (iNHL).
(BELG J HEMATOL 2017;8(4):141–3)
Read moreBJH - volume 8, issue 4, august 2017
T. Feys MBA, MSc
Treatment discontinuation has become a central issue in studies with BCR-ABL tyrosine kinase inhibitors (TKIs) in chronic myeloid leukemia (CML). The oral session on clinical trials in CML featured two studies on treatment discontinuation: one assessing initial reduction before complete TKI withdrawal and a second study evaluating the impact of minimal residual disease (MRD) on the outcome of imatinib discontinuation. In addition to this, a study was presented with long-term data on 400mg imatinib as first-line treatment for CML together with a study assessing frontline bosutinib. Finally, a last abstract in this session evaluated the second-generation BCR-ABL TKI dasatinib in children and adolescents with CML.
(BELG J HEMATOL 2017;8(4):151–4)
Read moreBJH - volume 8, issue 4, august 2017
T. Feys MBA, MSc
As usual, June was a very busy month for lymphoma specialists, with back to back, international meetings. This report will summarize some key data related to non-hodgkin lymphoma, presented during the 2017 International Conference on Malignant Lymphoma (ICML; Lugano June 14–17) and the 2017 annual meeting of the European Hematology Association (EHA; Madrid June 22–25). We would like to acknowledge Prof Ann Janssens (University Hospital Leuven) for her help in selecting the abstracts presented here.
(BELG J HEMATOL 2017;8(4):158–64)
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