Articles

P4.09 MPL S204P is a Recurrent Mutation in Essential Thrombocythemia

BJH - volume 7, issue Abstract Book BHS, january 2016

C. AL Assaf , P. Papadopoulos , S. Smits , L. Gutiérrez , I. Tanyalcin , M. Fierce , E. Lierman PhD, T. Devos MD, PhD, J. Billiet MD, P. Vandenberghe MD, PhD

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P4.10 The Ponatinib Named Patient Programme (NPP): Real-life Data from Belgian Patients

BJH - volume 7, issue Abstract Book BHS, january 2016

L. Knoops MD, PhD, G. Verhoef MD, PhD, Z. Berneman MD, PhD, D. Selleslag MD, N. Straetmans MD, PhD, L. Noens MD, PhD, P. Lewalle MD, PhD, M. André MD, PhD, D. Pranger MD, P. Zachée MD, PhD, E. Strobbe , L.J. McGarry , T. Devos MD, PhD

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Practical management of chronic myeloid leukaemia in Belgium

BJH - volume 6, issue 1, march 2015

F. S. Benghiat MD, PhD, Y. Beguin MD, PhD, B. Dessars MD, PhD, T. Devos MD, PhD, P. Lewalle MD, PhD, P. Mineur MD, N. Straetmans MD, PhD, K. Van Eygen MD, G. Verhoef MD, PhD, L. Knoops MD, PhD

Summary

Imatinib has drastically changed the outcome of patients with chronic myeloid leukaemia, with the majority of them showing a normal life span. Recently, the development of second and third generation tyrosine kinase inhibitors and the possibility of treatment discontinuation made the management of these patients more challenging. In this review, practical management guidelines of chronic myeloid leukaemia are presented adapted to the Belgian situation in 2014. In first line chronic phase patients, imatinib, nilotinib and dasatinib can be prescribed. While second generation tyrosine kinase inhibitors give faster and deeper responses, their impact on long-term survival remain to be determined. The choice of the tyrosine kinase inhibitor depends on chronic myeloid leukaemia risk score, priority for a deep response to allow a treatment-free remission protocol, age, presence of comorbid conditions, side effect profile, drug interactions, compliance concerns and price. Monitoring the response has to be done according the 2013 European LeukemiaNet criteria, and is based on the bone-marrow cytogenetic response during the first months and on the blood molecular response. Molecular follow-up is sufficient in patients with a complete cytogenetic response. For patients who fail frontline therapy, nilotinib, dasatinib, bosutinib and ponatinib are an option depending on the type of intolerance or resistance. T315I patients are only sensitive to ponatinib, which has to be carefully handled due to cardiovascular toxicity. Advanced phase diseases are more difficult to handle, with treatments including allogeneic stem cell transplantation, which is also an option for patients failing at least two tyrosine kinase inhibitors. The possibility of treatment-free remission and pregnancy are also discussed.

(BELG J HEMATOL 2015;6(1): 16–32)

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P3.02 Autologous Hematopoietic Stem Cell Transplantation in Crohn’s Disease: Results from our first 14 patients

BJH - volume 6, issue Abstract Book BHS, january 2015

D. Dierickx MD, PhD, A. Van Besien MD, S. Vermeire , G. Verhoef MD, PhD, M. Delforge MD, PhD, T. Devos MD, PhD, A. Janssens MD, PhD, J. Maertens MD, PhD, H. Schoemans MD, PhD

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P4.10 De novo thrombotic microangiopathy after non-renal solid organ transplantation

BJH - volume 6, issue Abstract Book BHS, january 2015

D. Dierickx MD, PhD, A. Verbiest , J. Pirenne , G. Verhoef MD, PhD, M. Delforge MD, PhD, T. Devos MD, PhD, A. Janssens MD, PhD, J. Maertens MD, PhD, H. Schoemans MD, PhD

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P2.03 Belgian Stop IMatinib trial

BJH - volume 6, issue Abstract Book BHS, january 2015

P. Mineur MD, C. Doyen MD, PhD, N. Straetmans MD, PhD, K. Van Eygen MD, D. Pranger MD, A. Bosly MD, PhD, M. André MD, PhD, T. Devos MD, PhD, L. Knoops MD, PhD

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P1.22 Characteristics, treatment and prognosis of primary central nervous system lymphoma: a single center retrospective study

BJH - volume 6, issue Abstract Book BHS, january 2015

D. Dierickx MD, PhD, A. van Mellaert , L. Smets , G. Verhoef MD, PhD, P. Clement MD, PhD, P. Demaerel , T. Tousseyn MD, PhD, M. Delforge MD, PhD, T. Devos MD, PhD, A. Janssens MD, PhD, J. Maertens MD, PhD, H. Schoemans MD, PhD

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