Articles

Guidance for the prevention and treatment of venous thromboembolism in cancer patients

BJH - volume 7, issue 6, december 2016

A. Awada MD, PhD, J-F. Baurain MD, PhD, P. Clement MD, PhD, P. Hainaut MD, PhD, S. Holbrechts MD, PhD, J-M. Hougardy , K. Jochmans MD, PhD, V. Mathieux MD, PhD, J. Mebis MD, PhD, M. Strijbos MD, PhD, C. Vulsteke MD, PhD, P. Verhamme MD, PhD

Summary

Venous thrombosis is a common complication in cancer patients and thromboembolism is the second most common cause of death. Several practice guidelines provide recommendations for the management of cancer-associated thrombosis. However, these guidelines do not sufficiently cover commonly encountered clinical challenges. With this expert panel, consisting of medical oncologists, haematologists, internists and thrombosis specialists, we aimed to develop a practical Belgian guidance for adequate prevention and treatment of cancer-associated thrombosis that covered several challenging situations encountered in daily clinic. This paper discusses the following topics: type and treatment duration of anticoagulant therapy, recurrent VTE despite anticoagulation, anticoagulation in case of renal impairment, liver disease and thrombocytopenia, the role of anti-Xa monitoring, central venous catheter-associated thrombosis, the position of direct oral anticoagulants and thromboprophylaxis, both in ambulatory and hospitalised patients. For an overview of the recommendations formulated by the expert panel, we refer to the key messages for clinical practice in this article.

(BELG J HEMATOL 2016;7(6):217–23)

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Addition of idarucizumab to plasma samples containing dabigatran allows to use routine coagulation assays to diagnose hemostasis disorders

BJH - volume 6, issue Abstract Book BSTH, november 2015

M. Peetermans , J. Toelen , J. Schoeters , K. Peerlinck MD, PhD, J. Van Ryn , T. Vanassche MD, PhD, P. Verhamme MD, PhD, M. Jacquemin MD, PhD

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Platelet Endothelial Aggregation Receptor 1: a novel modifier of neo-angiogenesis

BJH - volume 6, issue Abstract Book BSTH, november 2015

C. Vandenbriele MD, PhD, A. Kauskot , I. Vandersmissen , M. Criel , R. Geenens , S. Craps , A. Luttun , S. Janssens , M.F. Hoylaerts , P. Verhamme MD, PhD

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Dextran sulphate triggers platelet aggregation via direct activation of PEAR1

BJH - volume 6, issue Abstract Book BSTH, november 2015

C. Vandenbriele MD, PhD, Y. Sun , M. Criel , K. Cludts , S. van Kerckhoven , B. Izzi , T. Vanassche MD, PhD, P. Verhamme MD, PhD, M.F. Hoylaerts

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Identification of a novel staphylococcal binding partner for soluble von Willebrand factor-binding protein crucial for adhesion of Staphylococcus aureus to the vessel wall via von Willebrand factor

BJH - volume 6, issue Abstract Book BSTH, november 2015

J. Claes , M. Peetermans , L. Liesenborghs , T.R. Veloso , M.F. Hoylaerts , R. Heying , P. Verhamme MD, PhD, T. Vanassche MD, PhD

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Binding to von Willebrand factor enables S. lugdunensis to overcome shear stress and cause infective endocarditis

BJH - volume 6, issue Abstract Book BSTH, november 2015

L. Liesenborghs , M. Peetermans , J. Claes , M. Lox , K. Cludts , S. van Kerckhoven , prof. dr. W. Peetermans MD, PhD, T. Vanassche MD, PhD, M. Hoylaerts , P. Verhamme MD, PhD

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A-103 Rivaroxaban for the treatment of consumptive coagulopathy associated with vascular malformations

BJH - 2014, issue Abstract Book BSTH, november 2014

C. Vandenbriele MD, PhD, T. Vanassche MD, PhD, M. Peetermans , P. Verhamme MD, PhD, K. Peerlinck MD, PhD

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