BJH - volume 10, issue 3, may 2019
S. van Hecke MD, P. Vandenberghe MD, PhD, A. Janssens MD, PhD
Neutropaenia is a common incidental finding on routine blood studies. This manuscript will focus on the possible causes, challenging differential diagnosis and appropriate management of neutropaenia. Different mechanisms may explain a decreased production, impaired development or increased destruction of neutrophilic granulocytes. We distinguish between congenital and acquired causes. The former includes benign ethnic neutropaenia, severe congenital neutropaenia and cyclic neutropaenia. For the latter, infections, drugs, auto-immune reactions, nutritional deficiencies as well as haematological malignancies are all possible reasons of neutropaenia. The risk of infection in those with non-chemotherapy-induced neutropaenia mainly depends on the bone marrow reserve. Asymptomatic patients with mild or moderate neutropaenia can be observed with serial blood counts at increasing intervals. Infections should always be treated according to the severity of neutropaenia. Therapy with growth factors, drug discontinuation and immunosuppressive therapy can be considered depending on the underlying cause.
(BELG J HEMATOL 2019;10(3):103–12)
Read moreBJH - volume 10, issue Abstract Book BHS, february 2019
J. Finalet Ferreiro , T. Tousseyn MD, PhD, O. Gheysens MD, PhD, G. Verhoef MD, PhD, M. André MD, PhD, P. Vandenberghe MD, PhD, L. Buedts PhD, L.M. Fornecker , J. Lazarovici , R. Casasnovas , C. Copie , L. Marcelis MD, PhD
BJH - 2018, issue Abstract Book BHS, february 2018
T. Demuynck , P. Vandenberghe MD, PhD, G. Verhoef MD, PhD, T. Devos MD, PhD
BJH - 2018, issue Abstract Book BHS, february 2018
T. Eyckmans MD, S. Mahieu , M.P. Emonds MD, PhD, E. Lazarova , P. Vandenberghe MD, PhD, P. Zachée MD, PhD
BJH - 2018, issue Abstract Book BHS, february 2018
L. De Roeck , L. Michaux MD, PhD, K. Debackere MD, E. Lierman PhD, P. Vandenberghe MD, PhD, T. Devos MD, PhD
BJH - 2018, issue Abstract Book BHS, february 2018
Ir J. Van Ham , M. Delforge MD, PhD, A. Janssens MD, PhD, J. Raddoux , M. Beckers MD, PhD, T. Devos MD, PhD, D. Dierickx MD, PhD, V. Vergote MD, J. Maertens MD, PhD, H. Schoemans MD, PhD, P. Vandenberghe MD, PhD
BJH - 2018, issue Abstract Book BHS, february 2018
C. Debergh MD, D. Dierickx MD, PhD, P. Vandenberghe MD, PhD
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