Articles

Diagnostic testing in myeloid malignancies by next-generation sequencing: recommendations from the Commission Personalised Medicine

BJH - volume 10, issue 6, october 2019

E. Van Valckenborgh PhD, M. Bakkus PhD, E. Boone PhD, A. Camboni MD, PhD, J-P. Defour PhD, B. Denys MD, H. Devos MD, L. Dewispelaere MD, G. Froyen PhD, A. Hébrant PhD, P. Heimann MD, PhD, P. Hermans MD, PhD, E. Heylen PhD, K. Jacobs PhD, F. Lambert MD, M. Le Mercier Apr, PhD, E. Lierman PhD, H. Louagie MD, PhD, B. Maes MD, PhD, M-B. Maes PhD, G. Martens MD, PhD, L. Michaux MD, PhD, F. Nollet PhD, MSc, H.A. Poirel MD, PhD, G. Raicevic PhD, P. Saussoy MD, PhD, T. Tousseyn MD, PhD, M. Van Den Bulcke PhD, P. Vandenberghe MD, PhD, K. Vandepoele PhD, P. Vannuffel PhD, T. Venken PhD, K. Vermeulen PhD

SUMMARY

Molecular diagnostics have an increasing impact on diagnosis, risk stratification and targeted treatment in haemato-oncology. In the framework of a pilot study for the implementation of next-generation sequencing in the Belgian healthcare system, the Commission of Personalised Medicine was founded to give professional and evidence-based advice on the molecular analysis in haemato-oncology. This paper describes its recommendations for NGS analysis in myeloid malignancies. In addition, the minimally required set of genes that must be analysed is defined and algorithms for molecular workflow in myeloid malignancies are proposed.

(BELG J HEMATOL 2019;10(6):241–9)

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P16 Preleukemic phase of chronic myeloid leukemia presenting with an isolated peripheral basocytosis

BJH - 2018, issue Abstract Book BHS, february 2018

F. Dall’Armellina , Y. Berners , L. Maindiaux , A. Capes , J-P. Defour PhD, P. Saussoy MD, PhD, V. Havelange MD, PhD, M-C. Vekemans MD, PhD

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P61 Drug induced neutropenia with myelodysplasia with blast excess

BJH - 2018, issue Abstract Book BHS, february 2018

A. Capes , F. Dall’Armellina , Y. Berners , L. Maindiaux , T. Connerotte MD, A. Camboni MD, PhD, P. Saussoy MD, PhD, J-P. Defour PhD, X. Poiré MD, PhD, N. Straetmans MD, PhD, M-C. Vekemans MD, PhD

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PP31 Roles of microRNAs in myeloid malignancies driven by activated tyrosine kinases

BJH - volume 8, issue Abstract Book BHS, february 2017

M. Claus , A. Essaghir , P. Saussoy MD, PhD, L. Michaux MD, PhD, J.B. Demoulin , V. Havelange MD, PhD

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P38 Coexistence of inversion (16) et Bcr-Abl rearrangement in acute myeloid leulemia: a clinical description

BJH - volume 8, issue Abstract Book BHS, february 2017

J. Devreux , G. Di Prinzio , S. Bailly MD, S. Lefebvre , G. Verstraete , K. van Renterghem , A. Charlot , P. Saussoy MD, PhD, J-P. Defour PhD, N. Straetmans MD, PhD, X. Poiré MD, PhD, L. Michaux MD, PhD, M-C. Vekemans MD, PhD, V. Havelange MD, PhD

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P4.11 Unusual cutaneous paraneoplastic syndrome in the setting of acute myeloid leukemia

BJH - volume 7, issue Abstract Book BHS, january 2016

T. Tamakloe , N. Meité , S. Amat , P. Janssens , L. Marot , J-P. Defour PhD, P. Saussoy MD, PhD, H. Poirel MD, PhD, L. Michaux MD, PhD, E. Van den Neste MD, PhD, L. Knoops MD, PhD, V. Havelange MD, PhD, C. Lambert MD, X. Poiré MD, PhD, M-C. Vekemans MD, PhD

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P1.06 Bilateral Bell’s palsy leading to the diagnosis of chronic lymphocytic leukemia

BJH - volume 6, issue Abstract Book BHS, january 2015

C. Cornil , E. Collinge MD, G. Di Prinzio , A. Devresse , J-P. Defour PhD, P. Saussoy MD, PhD, L. Michaux MD, PhD, L. Knoops MD, PhD, M-C. Vekemans MD, PhD, A. Ferrant

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