BJH - volume 13, issue 7, november 2022
N. Kint MD, PhD, M. Delforge MD, PhD
Plasma cell leukaemia (PCL) is a rare and aggressive plasma cell malignancy and is generally considered to be the final stage of multiple myeloma (MM). Although treatment modalities for MM have significantly evolved in the past decades, PCL unfortunately still retains an overall dismal prognosis, with most patients presenting with a highly symptomatic and aggressive disease course. We present a case of a transplant-ineligible patient diagnosed with a primary PCL who had an indolent presentation and achieved a durable complete remission after treatment via bortezomib-lenalidomide-dexamethasone (VRD). The present case illustrates the clinical heterogeneity of plasma cell disorders, and highlights the necessity of careful cytomorphological and flow cytometric analysis of aberrant lymphoid cells, even in the absence of stigmata of MM.
(BELG J HEMATOL 2022;13(7):277–80)
Read moreBJH - volume 13, issue 2, march 2022
N. Kint MD, PhD, W. De Brouwer MD, R. Schots MD, PhD
The diagnostic and therapeutic landscape of multiple myeloma (MM) has been in constant evolution, resulting in many novel treatment opportunities for patients with MM, though many challenges remain in providing optimal care for patients with MM. In this article, several recent updates with regard to the diagnosis and treatment of MM, as presented at the 18th International Myeloma Workshop (IMW), have been summarised. In this summary, two main topics have been highlighted: 1) early treatment of high-risk smouldering MM, in combination with the development of non-invasive methods for risk stratification of smouldering MM, using circulating tumour cells and 2) updates on trials regarding novel treatment modalities, including novel combination regimens in newly diagnosed and relapsed MM patients, as well as novel immune therapies, with a focus on CAR-T cell therapy and bispecific antibodies.
(BELG J HEMATOL 2022;13(2):95–9)
Read moreBJH - volume 10, issue 8, december 2019
S. Vlayen MSc, N. Kint MD, PhD, M. Delforge MD, PhD
As the surface antigen CD38 is highly expressed on malignant plasma cells, it provides an interesting therapeutic target for the treatment of multiple myeloma (MM). At present, three anti-CD38 monoclonal antibodies (mAb) have been studied in MM: daratumumab, isatuximab and MOR202. All three anti-CD38 mAb show complement-dependent cytotoxicity (CDC), antibody-dependent cellular cytotoxicity (ADCC) and antibodydependent cellular phagocytosis (ADCP) activities. Moreover, immunomodulatory effects of daratumumab and isatuximab have been demonstrated. At present, daratumumab has been the most extensively studied anti-CD38 mAb in clinical trials. Following the excellent results of phase III clinical trials in relapsed/refractory MM (RRMM), daratumumab has recently also been studied in phase III clinical trials in newly diagnosed patients. The effects of isatuximab and MOR202 have been studied in phase III and phase I clinical trials, respectively, in patients with RRMM.
(BELG J HEMATOL 2019;10(8):326–31)
Read more
Top
To provide the best experiences, we and our partners use technologies like cookies to store and/or access device information. Consenting to these technologies will allow us and our partners to process personal data such as browsing behavior or unique IDs on this site and show (non-) personalized ads. Not consenting or withdrawing consent, may adversely affect certain features and functions.
Click below to consent to the above or make granular choices. Your choices will be applied to this site only. You can change your settings at any time, including withdrawing your consent, by using the toggles on the Cookie Policy, or by clicking on the manage consent button at the bottom of the screen.
