Articles

P.44 Donor cell-derived acute myeloid leukemia after allogeneic hematopoietic stem cell transplantation: molecular confirmation by next-generation sequencing

BJH - volume 11, issue Abstract Book BHS, february 2020

L. Nevejan , D. Selleslag MD, S. Huygens , B. Cauwelier MD, PhD, J. Emmerechts MD, PhD, H. Devos MD

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Spuriously high MCV in a patient with diabetic ketoacidosis

BJH - volume 10, issue 6, october 2019

A. Louwagie PharmD, M. Tajdar PharmD, B. Cauwelier MD, PhD, H. Devos MD, J. Robbrecht MD, S. Van Erum MD, J. Emmerechts MD, PhD

SUMMARY

We report a case of a falsely increased mean corpuscular volume (MCV) due to severe hyperglycaemia in a patient with diabetic ketoacidosis. This phenomenon results from in vitro swelling of hyperosmolar red blood cell size when diluted in an iso-osmolar buffer of a haematology analyser, and does not reflect a true macrocytosis in vivo. The magnitude of this effect is dependent on the glucose concentration of the sample and time of incubation prior to analysis. Haematology analysers from three different manufacturers were found equally sensitive to this phenomenon. Therefore, it is suggested to use reluctance when reporting and interpreting MCV results in the case of severe hyperglycaemia to avoid unnecessary additional investigation.

(BELG J HEMATOL 2019;10(6):250–4)

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Targeted next generation DNA sequencing for the detection of clonal haematopoiesis in idiopathic cytopaenia of undetermined significance (ICUS)

BJH - volume 10, issue 6, october 2019

Y. Wouters PharmD, F. Nollet PhD, MSc, B. Cauwelier MD, PhD, J. Emmerechts MD, PhD, D. Selleslag MD, H. Devos MD

SUMMARY

Patients lacking diagnostic criteria for myelodysplastic syndrome, but who show an unexplained persistent cytopaenia are classified as patients suffering from idiopathic cytopaenia of undetermined significance (ICUS). A fraction of these patients carry somatic mutations in genes which are also mutated in myeloid neoplasms. The significance of these mutations in ICUS patients is not well known and only few research papers have tried to correlate them with clinical outcome. ICUS patients carrying somatic mutations seem to have a higher progression rate to myeloid malignancies compared to unmutated patients. Some mutation profiles also show lower overall survival, similar to patients with (low-risk) myelodysplastic syndrome. Therefore, it seems useful to screen for somatic mutations in cytopaenic patients. The goal of this paper is to review recent literature regarding the significance of somatic mutations in cytopaenic patients and propose a screening protocol by evaluating a test protocol at the AZ Sint-Jan hospital Brugge-Oostende.

(BELG J HEMATOL 2019;10(6):231–40)

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P13 THE VALUE OF LABORATORY SCREENING VS. CLINICAL JUDGMENT IN HIT DIAGNOSIS: EXPERIENCES IN THREE BELGIAN HOSPITALS

BJH - 2019, issue ?, february 2019

K. Eeckhout , G. Glynis , J. Emmerechts MD, PhD, K. Schatteman , M-B. Maes PhD, E. Bailleul

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P49 Evaluation of the CellaVision DM96 Advanced RBC Application for screening and follow-up of malaria infection

BJH - 2018, issue Abstract Book BHS, february 2018

L. Florin , K. Maelegheer , A. Muyldermans , M. Van Esbroeck , E. Nulens , J. Emmerechts MD, PhD

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P12 Diagnostic utility of the lymphoid screening tube for Ogata score calculation in MDS investigation

BJH - 2018, issue Abstract Book BHS, february 2018

A. Muyldermans , L. Florin , H. Devos MD, B. Cauwelier MD, PhD, J. Emmerechts MD, PhD

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PP48 Validation of first trimester non-invasive fetal RhD genotyping for targeted antenatal anti-D prophylaxis

BJH - 2018, issue Abstract Book BHS, february 2018

B. Cauwelier MD, PhD, A. Van Haver , F. Nollet PhD, MSc, H. Devos MD, J. Emmerechts MD, PhD

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