Articles

Diagnostic testing in myeloid malignancies by next-generation sequencing: recommendations from the Commission Personalised Medicine

BJH - volume 10, issue 6, october 2019

E. Van Valckenborgh PhD, M. Bakkus PhD, E. Boone PhD, A. Camboni MD, PhD, J-P. Defour PhD, B. Denys MD, H. Devos MD, L. Dewispelaere MD, G. Froyen PhD, A. Hébrant PhD, P. Heimann MD, PhD, P. Hermans MD, PhD, E. Heylen PhD, K. Jacobs PhD, F. Lambert MD, M. Le Mercier Apr, PhD, E. Lierman PhD, H. Louagie MD, PhD, B. Maes MD, PhD, M-B. Maes PhD, G. Martens MD, PhD, L. Michaux MD, PhD, F. Nollet PhD, MSc, H.A. Poirel MD, PhD, G. Raicevic PhD, P. Saussoy MD, PhD, T. Tousseyn MD, PhD, M. Van Den Bulcke PhD, P. Vandenberghe MD, PhD, K. Vandepoele PhD, P. Vannuffel PhD, T. Venken PhD, K. Vermeulen PhD

SUMMARY

Molecular diagnostics have an increasing impact on diagnosis, risk stratification and targeted treatment in haemato-oncology. In the framework of a pilot study for the implementation of next-generation sequencing in the Belgian healthcare system, the Commission of Personalised Medicine was founded to give professional and evidence-based advice on the molecular analysis in haemato-oncology. This paper describes its recommendations for NGS analysis in myeloid malignancies. In addition, the minimally required set of genes that must be analysed is defined and algorithms for molecular workflow in myeloid malignancies are proposed.

(BELG J HEMATOL 2019;10(6):241–9)

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PP02 Monocentric retrospective study of 138 therapy-related myeloid neoplasms

BJH - 2018, issue Abstract Book BHS, february 2018

H. Claerhout MD, E. Lierman PhD, L. Michaux MD, PhD, G. Verhoef MD, PhD, N. Boeckx MD, PhD

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P17 Concurrent driver mutations in MPN: clinical and molecular characteristics of a series of 11 patients

BJH - 2018, issue Abstract Book BHS, february 2018

L. De Roeck , L. Michaux MD, PhD, K. Debackere MD, E. Lierman PhD, P. Vandenberghe MD, PhD, T. Devos MD, PhD

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P36 Next generation sequencing in patients with therapy-related myeloid neoplasms

BJH - volume 8, issue Abstract Book BHS, february 2017

H. Claerhout MD, E. Lierman PhD, D. Kieffer PhD, PharmD, N. Boeckx MD, PhD

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P57 Comparison of the a-Globin StripAssay® and MLPA® as a diagnostic tool for a-thalassaemia

BJH - volume 8, issue Abstract Book BHS, february 2017

H. Claerhout MD, J. Oosterbosch , C.L. Harteveld , E. Lierman PhD, D. Kieffer PhD, PharmD

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P3.02 Ponatinib as bridge to haematopoietic stem cell transplantation in a patient with a myeloid/lymphoid neoplasm with eosinophilia and abnormality of FGFR1: a case report

BJH - volume 7, issue Abstract Book BHS, january 2016

H. Maes , J. Maertens MD, PhD, S. Smits , E. Lierman PhD, N. Boeckx MD, PhD, T. Tousseyn MD, PhD, G. Verhoef MD, PhD, P. Vandenberghe MD, PhD

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P4.09 MPL S204P is a Recurrent Mutation in Essential Thrombocythemia

BJH - volume 7, issue Abstract Book BHS, january 2016

C. AL Assaf , P. Papadopoulos , S. Smits , L. Gutiérrez , I. Tanyalcin , M. Fierce , E. Lierman PhD, T. Devos MD, PhD, J. Billiet MD, P. Vandenberghe MD, PhD

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