Articles

P13 In vitro generation of tumor antigen-specific T cells from patient and healthy donor stem cells

BJH - 2018, issue Abstract Book BHS, february 2018

S. Bonte PhD, S. Snauwaert MD, PhD, G. Goetgeluk , B. Vandekerckhove MD, PhD, T. Kerre MD, PhD

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O.4 In vitro generation of tumor antigen-specific T cells from patient and healthy donor stem cells

BJH - volume 8, issue Abstract Book BHS, february 2017

S. Bonte PhD, S. Snauwaert MD, PhD, G. Goetgeluk , B. Vandekerckhove MD, PhD, T. Kerre MD, PhD

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PP4.5 Functional in vitro evaluation of T cells generated from minor H antigen-TCR transduced human hematopoietic stem cells using the OP9-DL1 coculture system

BJH - volume 7, issue Abstract Book BHS, january 2016

S. Bonte PhD, S. Snauwaert MD, PhD, M. Heemskerk , B. Vandekerckhove MD, PhD, T. Kerre MD, PhD

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P2.07 Characterization of a novel innate CD8+ T cell lineage generated in human thymus

BJH - volume 7, issue Abstract Book BHS, january 2016

G. Verstichel , G. Goetgeluk , L. Martens , T. Taghon , G. Leclercq , T. Kerre MD, PhD, Y. Saeys , B. Vandekerckhove MD, PhD

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P2.01 Functional evaluation of T cells generated from WT1-TCR transduced human hematopoietic stem cells using the OP9-DL1 coculture system

BJH - volume 6, issue Abstract Book BHS, january 2015

S. Bonte PhD, S. Snauwaert MD, PhD, G. Goetgeluk , M.H.M. Heemskerk , H. Stauss , R. Stripecke , B. Vandekerckhove MD, PhD, T. Kerre MD, PhD

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In vitro generation of AML-specific T-cells from human haematopoietic progenitor cells. A step towards curing acute myeloid leukaemia?

BJH - volume 5, issue 4, december 2014

S. Snauwaert MD, PhD, B. Vandekerckhove MD, PhD, T. Kerre MD, PhD

Summary

This dissertation focuses on T-cell-mediated immunotherapeutic strategies for the treatment of acute myeloid leukaemia. Two major key points determine the success of adoptive T-cell therapy: the nature of the target antigen and the characteristics of the infused T-cells. We reviewed potential acute myeloid leukaemia target antigens and performed an in-depth study of the Receptor for Hyaluronic Acid Mediated Motility as a potential leukaemia associated antigen. Subsequently, an alternative immunotherapeutic strategy was studied: the in vitro generation of antigen-specific T-cells starting from T-cell receptor-transduced human haematopoietic progenitor cells.

(BELG J HEMATOL 2014;5(4):154–7)

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P4.11 Genetic correction of induced pluripotent stem cells from a Wiskott-Aldrich Syndrome patient normalizes the immune defects

BJH - volume 5, issue Abstract Book BHS, january 2014

Y. Van Caeneghem , R. Pourebrahimabadi , T. Laskowski , Z. Garate , A. Crane , J.C. Segovia , M. Holmes , B. Vandekerckhove MD, PhD, B. Davis

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