Articles

Erythropoiesis and iron metabolism after haematopoietic stem cell transplantation

BJH - volume 10, issue 2, march 2019

A. Jaspers MD, PhD, Y. Beguin MD, PhD

After haematopoietic stem cell transplantation (HCT), many patients present anaemia, which can persist for months due to an inadequate erythropoietin production for the degree of the anaemia. In this thesis, we performed two randomised studies with erythropoiesis-stimulating agents therapy after allogeneic (including myeloablative and non-myeloablative conditioning) and autologous transplantation. We showed a great efficacy of this growth factor to ensure full erythroid reconstitution when initiated soon after engraftment and not immediately after the transplant. Furthermore, as iron parameters are quite disturbed following HCT, we sought to study iron metabolism after HCT (which has not been much investigated), integrating the role of hepcidin, the key regulator in iron metabolism. Hence, we demonstrated that hepcidin levels prior to and following autologous HCT were influenced by iron stores and changes in erythropoietic activity.

(BELG J HEMATOL 2019;10(2):89–95)

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P78 Outcome of patients with hepatic sinusoidal obstruction syndrome admitted in the intensive care unit

BJH - volume 8, issue Abstract Book BHS, february 2017

A. Jaspers MD, PhD

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P3.05 Long-term safety follow-up of a randomized trial of darbepoetin alpha and intravenous iron following autologous hematopoietic cell transplantation

BJH - volume 6, issue Abstract Book BHS, january 2015

A. Jaspers MD, PhD, prof. F. Baron , J. Maertens MD, PhD, B. De Prijck MD, R. Schots MD, PhD, C. Bonnet MD, PhD, K. Hafraoui , E. Willems MD, PhD, S. Servais MD, PhD, G. Fillet , Y. Beguin MD, PhD

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O.6 Long-term survival in patients receiving rhEPO following allogeneic hematopoietic cell transplantation

BJH - volume 5, issue Abstract Book BHS, january 2014

A. Jaspers MD, PhD, prof. F. Baron , E. Willems MD, PhD, K. Hafraoui , C. Bonnet MD, PhD, Y. Beguin MD, PhD

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P4.05 High incidence of second malignancies in patients given allogeneic hematopoietic stem cell transplantation following reduced-intensity (RIC) or nonmyeloablative conditioning

BJH - volume 5, issue Abstract Book BHS, january 2014

prof. F. Baron , M. Lejeune , E. Willems MD, PhD, L. Seidel , K. Hafraoui , S. Servais MD, PhD, A. Jaspers MD, PhD, Y. Beguin MD, PhD

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O.7 Erythropoietin therapy after allogeneic hematopoietic cell transplantation : a prospective randomised trial

BJH - 2013, issue BHS Abstractbook, january 2013

A. Jaspers MD, PhD, prof. F. Baron , E. Willems MD, PhD, K. Hafraoui , G. Vanstraelen , C. Bonnet MD, PhD, Y. Beguin MD, PhD

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P.56 Serum hepcidin following autologous haematopoietic cell transplantation : an illustration of the interplay of erythropoiesis, iron status and inflammation

BJH - 2013, issue BHS Abstractbook, january 2013

A. Jaspers MD, PhD, prof. F. Baron , E. Willems MD, PhD, E. Wiegerinck , D. Swinkels , Y. Beguin MD, PhD

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