Described for the first time in 2020, VEXAS, an adult-onset ‘haemato-inflammatory syndrome’, is still largely unexplored. At the 2024 General Annual Meeting of the Belgian Hematology Society, Dr. Jérome Hadjadj (Hôpital Saint-Antoine, Paris, France) discussed the current understanding of this disease, covering its clinical manifestations, prognosis and potential treatments based on the knowledge available to date.