D–dimer (DD) assay is a widely used laboratory test in thrombosis-related conditions because it is rapid and easy to perform. This test is highly sensitive to thrombus formation and degradation. However DD levels are increased in many clinical conditions so that its positive predictive value is poor. Improvements of its usefulness have been mainly realised by combining the test with clinical scores and by adapting positive threshold to particular settings of patients. In this article, different methods of DD testing are presented with the aim to review their benefits and pitfalls in various clinical applications.

(BELG J HEMATOL 2013;4(2):47–50)