Paroxysmal nocturnal haemoglobinuria (PNH) is a rare hematopoietic stem cell disorder resulting from the somatic mutation of the X-linked PIGA gene. PNH has a very heterogeneous clinical presentation and the treatment for PNH patients depends on the severity of symptoms and the degree of hemolysis. In a special lecture at the 2021 BHS general annual meeting. Dr. Bérangère Devalet and Prof. Nicole Straetmans gave an overview of the current PNH landscape, from diagnosis to management.