High-risk haematology patients present with a partial or totally disintegrated immune system. Consequently, infections remain one of the main causes of morbidity and mortality among these patients. During the 37th general annual meeting of the Belgian Haematology Society, Prof. Johan Maertens (University Hospital Leuven, Leuven, Belgium), walked us through the current advances in the management of infections in high-risk haematology patients, with a focus on patients undergoing aggressive chemotherapy for any type of leukaemia and allogenic non-transplanted siblings.