Myelofibrosis (MF) management poses a significant challenge, with allogeneic stem cell transplantation (SCT) standing as the sole curative option, yet only viable for 15% of patients. During the 2024 General Annual Meeting of the Belgian Hematology Society, Prof. Timothy Devos (UZ Leuven, Belgium) offered an insightful overview of both current treatments and promising future therapeutic strategies for managing MF.