In the field of red blood cell disorders, ASH 2019 mainly focused on sickle cell disease (SCD). Current disease-modifying therapeutic options for SCD consist of hydroxyurea and chronic transfusions but none of them can fully prevent complications and both have their drawbacks. A haematopoietic stem cell transplantation is the only curative option to date. Yet, frequently a compatible donor is missing. ASH 2019 featured several abstracts on optimising disease-modifying therapies as well as curative options, such as gene therapy. A selection of abstracts is discussed below.

(BELG J HEMATOL 2020;11(1):21–6)