In recent years, the treatment landscape of patients with relapsed refractory multiple myeloma (RRMM) changed dramatically following a long list of positive phase III studies evaluating novel treatment combinations. During EHA 2018 several new positive studies were added to this list, further broadening the treatment armamentarium for RRMM. Following the successes in the RR setting, several of these novel agents are now also being explored in newly diagnosed MM (NDMM) patients. At EHA 2018, updated results were presented with the daratumumab-VMP combination in older NDMM patients. In addition, the role of VRD consolidation in NDMM was assessed and overall survival (OS) data of the GIMEMA-MMY-3006 study were presented. The key messages of these and other studies will be discussed in this summary.

(BELG J HEMATOL 2018;9(4):141–5)