Hundreds of oral- and poster presentations were communicated during the 61st Annual Meeting of ASH in San Diego. Of course, it is impossible to cover all topics and give detailed highlights. In this presentation, I will give you my ‘favourites’, sometimes in a historical perspective. For a more complete overview of congress highlights, I refer to the other articles in this special issue of the BJH.

(BELG J HEMATOL 2020;11(1):3–8)