This case report describes the diagnosis and treatment of hepatosplenic candidasis (or chronic disseminated candidiasis) in a young man with acute myeloid leukaemia (AML). The disease is characterized by persisting fever during treatment with broad-spectrum antibiotics after neutropenia. Sometimes the preceded candidemia is detected. The diagnosis can be made, using radiographic imaging (CT scan/PET scan), supported by histologic examination of a (liver) biopsy. Cultures can be negative. The β-D-glucan test and PCR assays might be of supportive value. Long-term antifungal medication (several months) is necessary. In some cases, fever only disappears after the start of corticosteroids.

(BELG J HEMATOL 2022;13(8):321–4)