At the ASCO 2023 conference, a dedicated session focused on exploring the most recent advancements in the management of haematological malignancies. CAR therapy brought promising results for acute lymphoblastic leukaemia (ALL), spanning B-ALL with obe-cel and brexu-cel and introducing CD5 CAR-T cells for T-ALL patients. Notably, combining inotuzumab ozogamicin with blinatumomab or DA-EPOCH chemotherapy achieved significant efficacy in ALL patients. Additionally, an observational study underscored the critical importance of treating adolescents and young adults with ALL at specialised cancer centres. In acute myeloid leukaemia (AML), the trifunctional NK cell engager SAR44359 displayed promising anti-leukaemic activity. Finally, luspatercept and the telomerase inhibitor imetelstat boosted transfusion independence and haemoglobin levels in myelodysplastic syndrome patients.

(BELG J HEMATOL 2023;14(7):313–9)