The management of acute promyelocytic leukaemia has evolved considerably. The standard front-line approach with all-trans retinoic acid and chemotherapy has recently been challenged by the chemo-free combination of all-trans retinoic acid and arsenic trioxide, which has emerged as the new standard of care for non-high-risk disease. This review gives an update of the management of acute promyelocytic leukaemia.

(BELG J HEMATOL 2016;7(6):224–8)