Elevated thrombopoietin levels may serve as biomarker for high risk of severe COVID-19

October 2022 Covid-19 Nalinee Pathak
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Researchers have reported that the levels of thrombopoietin (THPO), a growth factor essential to megakariocyte proliferation, are elevated in COVID-19 patients. THPO can be used as an early biomarker for COVID-19 and identify patients who may develop crtitical illness during the course of the disease. These findings were recently published in the journal eBioMedicine.

COVID-19 patients often develop inflammatory complications referred to as “cytokine storm” and is associated with high levels of interleukin 6 (IL-6). These changes lead to disturbances in coagulation and activation of platelets. THPO is a crucial factor that regulates platelet activation, and its levels are elevated in several critical diseases. Researchers have evaluated the potential use of IL-6 and THPO as diagnostic and prognostic markers for COVID-19 severity.

Study Design

The prospective cohort study enrolled 66 patients presenting in the emergency department with COVID-19 symptoms. Forty-seven patients were COVID-19 positive, and the remaining 19 were negative; hence, they were excluded from the study. The study also included 18 individuals as controls. The study has explored the THPO levels in the plasma of COVID-19 patients and its role in priming platelet activation in vitro.

Main Findings

The researchers found that the levels of THPO were elevated in COVID-19 patients as compared to non-COVID-19 patients and healthy controls. Also, plasma from COVID-19 primes in vitro platelet activation.


The study’s findings show that THPO can be used as an early biomarker for COVID-19 patients at risk of developing critical illness. Further, elevated THPO may enhance platelet activation and leukocyte-platelet interaction in COVID-19 patients.


Lupia E, Capuano M, Vizio B, Schiavello M, et al. Thrombopoietin participates in platelet activation in COVID-19 patients. EBioMedicine. 2022 Oct 12;85:104305.