Radiotherapy as bridging strategy in large B-cell lymphoma patients selected for CAR T-cell therapy

BJH - volume 15, issue 2, march 2024

A.G.H. Niezink MD, R.W.M. van der Maazen MD, PhD, B.D.P. Ta MSc, H. Vos-Westerman MD, C.P.M. Janus MD, L.A. Daniels MD, PhD


Chimeric antigen receptor T-cell (CAR T-cell) therapy is available in the Netherlands as a third-line treatment option in patients with large B-cell lymphoma. Bridging is often required during the waiting period between leukapheresis and CAR T-cell infusion. Radiotherapy is an increasingly applied bridging strategy, which is well tolerated by patients and also safe and effective. The most commonly used radiation schedule is 20 Gy in five fractions. In addition to bridging, radiotherapy can also be used as consolidation or salvage treatment after CAR T-cell therapy. Involving a radiation oncologist in a timely manner for patients who are going to be treated with CAR T-cell therapy is of benefit.

(BELG J HEMATOL 2024;15(2):37–42)

Read more