Acquired haemophilia A

BJH - volume 10, issue 4, june 2019

R.E.G. Schutgens MD, PhD, K. van Galen MD

Acquired haemophilia A is a potentially severe condition characterised by spontaneous bleeding episodes. Direct recognition and prompt treatment are mandatory. Diagnostic coagulation assays show an isolated prolonged activated partial thromboplastin time, not correcting in a mixing assay. An isolated decrease of factor VIII activity together with the presence of a neutralising antibody confirm the diagnosis. Treatment consists of cessation of a possible bleed and the eradication of the neutralising antibody.

(BELG J HEMATOL 2019;10(4):146–52)

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