Articles

Diagnostic testing in myeloid malignancies by next-generation sequencing: recommendations from the Commission Personalised Medicine

BJH - volume 10, issue 6, october 2019

E. Van Valckenborgh PhD, M. Bakkus PhD, E. Boone PhD, A. Camboni MD, PhD, J-P. Defour PhD, B. Denys MD, H. Devos MD, L. Dewispelaere MD, G. Froyen PhD, A. Hébrant PhD, P. Heimann MD, PhD, P. Hermans MD, PhD, E. Heylen PhD, K. Jacobs PhD, F. Lambert MD, M. Le Mercier Apr, PhD, E. Lierman PhD, H. Louagie MD, PhD, B. Maes MD, PhD, M-B. Maes PhD, G. Martens MD, PhD, L. Michaux MD, PhD, F. Nollet PhD, MSc, H.A. Poirel MD, PhD, G. Raicevic PhD, P. Saussoy MD, PhD, T. Tousseyn MD, PhD, M. Van Den Bulcke PhD, P. Vandenberghe MD, PhD, K. Vandepoele PhD, P. Vannuffel PhD, T. Venken PhD, K. Vermeulen PhD

SUMMARY

Molecular diagnostics have an increasing impact on diagnosis, risk stratification and targeted treatment in haemato-oncology. In the framework of a pilot study for the implementation of next-generation sequencing in the Belgian healthcare system, the Commission of Personalised Medicine was founded to give professional and evidence-based advice on the molecular analysis in haemato-oncology. This paper describes its recommendations for NGS analysis in myeloid malignancies. In addition, the minimally required set of genes that must be analysed is defined and algorithms for molecular workflow in myeloid malignancies are proposed.

(BELG J HEMATOL 2019;10(6):241–9)

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PP53 Unexplained anaemia in the Elderly: High prevalence of functional iron deficiency and underdiagnosed myelodysplasia

BJH - volume 8, issue Abstract Book BHS, february 2017

L. Sattar , M. Maerevoet MD, D. Bron MD, PhD, B. Cantinieaux , P. Hermans MD, PhD, T. Pepersack MD, PhD

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PP2.5 Hypercoagulability in adult sickle cell patients as compared to sickle cell trait subjects and a control group

BJH - volume 7, issue Abstract Book BHS, january 2016

B. Mahadeb , D. Noubouossie MD, L. Rozen PharmD, T. Besse-Hamme , A. Efira MD, P. Hermans MD, PhD, B. Gulbis MD, PhD, M.A. Azerad MD, A. Demulder MD, PhD

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P4.05 Anemia in a geriatric hospitalized population: an old disorder

BJH - volume 6, issue Abstract Book BHS, january 2015

L. Sattar , P. Hermans MD, PhD, T. Pepersack MD, PhD

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Thrombin generation in the plasma of sickle cell trait adults shows prothrombotic profile as compared to normal adults

BJH - 2014, issue Abstract Book BSTH, november 2014

L. Dewispelaere MD, B. Mahadeb , L. Rozen PharmD, D. Noubouossie MD, T. Besse-Hamer , A. Efira MD, P. Hermans MD, PhD, B. Gulbis MD, PhD, M.A. Azerad MD, A. Demulder MD, PhD

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