Articles

Clinical case: High grade “triple hit” Lymphoma

BJH - volume 12, issue 7, november 2021

G. Sqalli MD, T. Connerotte MD, B. Lambert MD, L. Dierge PharmD, T. Roy , J. Simar MD

SUMMARY

We report the case of a 64-year-old patient, known for follicular lymphoma, admitted with facial paralysis accompanied by acute cervicobrachialgia. A lumbar puncture revealed the presence of centroblastic lymphoma cells whose clonal nature was confirmed by immunophenotyping. The histological examination of a lymph node biopsy was consistent with Burkitt-like high-grade lymphoma. Cytogenetic analysis showed the concomitant presence of a rearrangement of MYC as well as of BCL2 and BCL6. A final diagnosis of “triple-hit” high-grade B cell lymphoma (HGBL) was thus made. This entity belongs to the HGBL category of the WHO 2016 classification and shares characteristics with diffuse large B-cell lymphoma and Burkitt lymphoma. The diagnosis of this entity can be complex, in particular in view of a significant morphological variability. The cytogenetic work-up is thus essential for the differential diagnosis.

(BELG J HEMATOL 2021;12(7):318–22)

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P.23 Heavy/light chain (HLC) and free light chain (FLC) analysis allow sensitive monitoring of multiple myeloma patients and aid detection of clonal changes

BJH - 2013, issue BHS Abstractbook, january 2013

L. Dierge PharmD, L. Lutteri , D. Chauvet , D. Hastir , J.P. Chapelle , E. Cavalier

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P.47 Impact of the oral and direct Factor Xa inhibitor Rivaroxaban on five routine coagulation assays, an in-vitro and ex-vivo study

BJH - 2013, issue BHS Abstractbook, january 2013

L. Dierge PharmD, E. Fosse , A. Alewaeters , D. Govaerts , P. Cauchie

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