BJH - 2013, issue BHS Abstractbook, january 2013
I. Meyts , D. Blockmans , F. Temmerman , X. Bossuyt , G. Diaz , M. Slatter , D. Dierckx
BJH - 2013, issue BHS Abstractbook, january 2013
I. Meyts , H. Schaballie , F. Haerynck MD, PhD, L. Sevenants , C. Vermylen , V. Bordon MD, PhD, X. Bossuyt , A. Corveleyn , A. Uyttebroeck MD, PhD, M. Renard
BJH - 2013, issue BHS Abstractbook, january 2013
I. Meyts , L. de Somer , X. Bossuyt , M. Morren , K. Devriendt , C. Wouters
BJH - 2013, issue BHS Abstractbook, january 2013
I. Meyts , T. van Ackere , A. Allemon , M. Proesmans , A.M. Rentmeesters
BJH - volume 3, issue 2, june 2012
S. Huybrechts MD, Y. Beguin MD, PhD, V. Bordon MD, PhD, MF. Dresse , S. Dupont MD, A. Ferster MD, PhD, G. Laureys MD, PhD, I. Meyts , M. Renard , C. Vermylen
Busulfan is commonly used in preparative conditioning regimens prior to haematopoietic stem cell transplantation in children and young adults for malignant and non-malignant disorders. For many years busulfan was only available in oral form, resulting in large inter- and intra-patients variability in plasma exposure, associated with higher graft failure rate as well as higher toxicity such as veno-occlusive disease. With the development of an intravenous formulation of busulfan, a more accurate control of both the inter- and intra-patient variability has been provided. The goal of this study was to evaluate the use and efficacy of intravenous busulfan in comparison with the oral formulation in children undergoing an autologous transplantation after conditioning with busulfan. Despite the small number of patients, this study confirmed the apparent benefit of intravenous busulfan in children undergoing an autologous HSCT. The use of a five-level dose schedule defined by body weight resulted in an efficient engrafitment with marked reduction in the incidence of veno-occlusive disease compared with oral busulfan. In terms of disease-free outcome, survival and event-free survival, similar results have been obtained in both groups. The choice of this formulation of busulfan should therefore be considered.
(BELG J HEMATOL 2012;3:34–40)
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