Articles

P35 In-house developed 15-gene sequencing panel for acute myeloid leukemia and myelodysplasia allows robust detection of genetic defects including FLT3-ITD and CEBPA mutations

BJH - volume 8, issue Abstract Book BHS, february 2017

B. Denys MD, J. Van der Meulen , E. de Latter , S. Lefever , T. Rosseel , W. Steyaert , G. Vandercruyssen , I. Rottiers , D. Creytens , dr. J. Van Dorpe , F. Speleman PhD, B. Poppe , N. Van Roy PhD, K. de Leeneer , K. Claes , K. Vandepoele PhD

Read more

Juvenile myelomonocytic leukaemia: the quest for more specific therapies

BJH - volume 5, issue 4, december 2014

H. Helsmoortel PhD, T. Lammens PhD, N. Van Roy PhD, J. Philippé MD, PhD, P. De Paepe MD, PhD, Y Benoit MD, PhD, F. Speleman PhD, P. Van Vlierberghe PhD, B. De Moerloose MD, PhD

Summary

Juvenile myelomonocytic leukaemia is a very rare, aggressive stem cell disorder predominantly affecting infants and young children. Current survival rates are disappointing and the only available curative therapy is haematopoietic stem cell transplantation. Over the last years, intensive research efforts elucidated a plethora of molecular aberrations involved in the pathogenesis of juvenile myelomonocytic leukaemia. Current investigations are mainly directed towards the complete unravelling of the molecular biology behind the disease in order to find more specific drugs. This review will focus on the diagnosis, genomic characterisation and the use of experimental therapies in juvenile myelomonocytic leukaemia.

(BELG J HEMATOL 2014; 5(4): 119–24)

Read more

P.02 H3K27me3 erasers, novel targets in T-cell acute lymphoblastic leukaemia

BJH - 2013, issue BHS Abstractbook, january 2013

J. Van der Meulen , K. Mavrakis , V. Sanghvi , B. Poppe , N. Van Roy PhD, P. Rondou , Y Benoit MD, PhD, P. Van Vlierberghe PhD, H. Wendel , F. Speleman PhD

Read more

P.03 Extending the functional redundant cooperative miRNA tumour suppressor and oncogene network in T-ALL

BJH - 2013, issue BHS Abstractbook, january 2013

E. Mets , G. van Peer , J. Van der Meulen , P. Mestdagh , T. Taghon , D. Avran , Y Benoit MD, PhD, B. Poppe , J. Soulier , P. Van Vlierberghe PhD, P. Rondou , J. Vandesompele , F. Speleman PhD

Read more

P.31 Study of the miRNome of childhood myelodysplastic syndrome

BJH - 2013, issue BHS Abstractbook, january 2013

H.H. Helsmoortel , T. Lammens PhD, N. Van Roy PhD, A. Uyttebroeck MD, PhD, A. Ferster MD, PhD, Y Benoit MD, PhD, F. Speleman PhD, B. De Moerloose MD, PhD

Read more

P.37 Incidental diagnosis of Fanconi anemia in an adult patient with myelodysplastic syndrome

BJH - 2013, issue BHS Abstractbook, january 2013

B. Poppe , E. Steel , S. Callens MD, PhD, K. Bonte , A. d’Heedene , F. Speleman PhD, B. Menten , N. Van Roy PhD

Read more