BJH - volume 4, issue 3, september 2013
A.C. Weidenaar MD, PhD, A. ter Elst PhD, W.A. Kamps MD, PhD, E.S. de Bont MD, PhD
The research described in this thesis aimed to explore the various mechanisms by which vascular endothelial growth factor A promotes acute myeloid leukaemia progression via autocrine and/or paracrine mechanisms, e.g. angiogenesis. Special attention was focused on new potential small-molecule-inhibitors and antibodies interfering with vascular endothelial growth factor/vascular endothelial growth factor receptor signalling. We showed that interference with vascular endothelial growth factor A/vascular endothelial growth factor receptor signalling induces cell death in (paediatric) acute myeloid leukaemia blasts and primitive cells. Furthermore, we studied angiogenesis in bone marrow of acute myeloid leukaemia patients and identified different morphology patterns, related to treatment outcome.
(BELG J HEMATOL 2013;4(3): 112–114)
Read more
Top
To provide the best experiences, we and our partners use technologies like cookies to store and/or access device information. Consenting to these technologies will allow us and our partners to process personal data such as browsing behavior or unique IDs on this site and show (non-) personalized ads. Not consenting or withdrawing consent, may adversely affect certain features and functions.
Click below to consent to the above or make granular choices. Your choices will be applied to this site only. You can change your settings at any time, including withdrawing your consent, by using the toggles on the Cookie Policy, or by clicking on the manage consent button at the bottom of the screen.
