Articles

A-107 DIFFERENCES IN HEPARIN AND ENOXAPARIN SENSITIVITY OF THREE COMMERCIALLY AVAILABLE PT REAGENTS

BJH - volume 9, issue Abstract Book BSTH, february 2018

A-S. De Koninck PharmD, E. Bailleul

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A-120 INFLUENCE OF ENOXAPARIN (CLEXANE®) ON LUPUS ANTICOAGULANT TESTING WITH HEMOSIL DRVVT (IL) AND HEMOSIL SCT (IL) ON ACL TOP

BJH - volume 9, issue Abstract Book BSTH, february 2018

A-S. De Koninck PharmD, E. Bailleul

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A case report of a paediatric Early T-cell Precursor Lymphoblastic Leukaemia

BJH - volume 8, issue 2, march 2017

A-S. De Koninck PharmD, C. Dhooge MD, PhD, B. Denys MD, K. Vandepoele PhD, N. Van Roy PhD, M. Hofmans MD, PhD, J. Philippé MD, PhD

SUMMARY

We describe a case of a four-year-old boy diagnosed with an Early T-cell Precursor Lymphoblastic Leukaemia. This type of leukaemia is recognised as a high-risk subgroup characterised by very early arrest in T-cell differentiation. Early T-cell Precursor Lymphoblastic Leukaemia cases have characteristic gene expression profiles, increased genomic instability and a distinct immature immunophenotype (CD1a–, CD8–, CD5+dim and positivity for at least one marker of stem cell or myeloid lineage). This type of leukaemia is associated with poor prognosis and a poor response to intensive chemotherapy, though this finding is still debated. Our patient displayed an inferior response to induction therapy. The main purpose of this report is to make Belgian physicians aware of this entity and its controversial prognostic significance.

(BELG J HEMATOL 2017;8(2):75–9)

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