A.C. Weidenaar MD, PhD, A. ter Elst PhD, W.A. Kamps MD, PhD, E.S. de Bont MD, PhD
The research described in this thesis aimed to explore the various mechanisms by which vascular endothelial growth factor A promotes acute myeloid leukaemia progression via autocrine and/or paracrine mechanisms, e.g. angiogenesis. Special attention was focused on new potential small-molecule-inhibitors and antibodies interfering with vascular endothelial growth factor/vascular endothelial growth factor receptor signalling. We showed that interference with vascular endothelial growth factor A/vascular endothelial growth factor receptor signalling induces cell death in (paediatric) acute myeloid leukaemia blasts and primitive cells. Furthermore, we studied angiogenesis in bone marrow of acute myeloid leukaemia patients and identified different morphology patterns, related to treatment outcome.