BJH - volume 5, issue Abstract Book BHS, january 2014
A. Jaspers MD, PhD, prof. F. Baron , E. Willems MD, PhD, K. Hafraoui , C. Bonnet MD, PhD, Y. Beguin MD, PhD
BJH - volume 5, issue Abstract Book BHS, january 2014
M. Binsfeld , R. Heusschen PhD, V. Lamour , E. Van Valckenborgh PhD, A. Bellahcène , prof. F. Baron , Y. Beguin MD, PhD, J. Caers MD, PhD
BJH - volume 5, issue Abstract Book BHS, january 2014
S. Sid MD, D. Dugauquier , B. De Prijck MD, C. Bonnet MD, PhD, Y. Beguin MD, PhD
BJH - volume 5, issue Abstract Book BHS, january 2014
J. Muller MSc, J. Caers MD, PhD, M. Binsfeld , S. Dubois , G. Carmeliet , Y. Beguin MD, PhD, R. Heusschen PhD
BJH - volume 4, issue 1, march 2013
A. Janssens MD, PhD, C. Lambert MD, G. Bries MD, PhD, A. Bosly MD, PhD, D. Selleslag MD, Y. Beguin MD, PhD
The Belgian Hematological Society (BHS) guideline panel on adult primary immune thrombocytopenia (ITP) reviewed the recent literature on diagnosis and treatment to make recommendations on the best strategies for frontline and subsequent-line treatment. No treatment is necessary for patients with platelet counts higher than 30000/μl in the absence of bleeding symptoms. Patients newly diagnosed or relapsing after a long-term treatment-free period can be managed with corticosteroids with or without intravenous immunoglobulins. A second line therapy is indicated for those patients who are intolerant or unresponsive to or relapse after initial corticosteroid treatment and have a risk of bleeding. The guideline panel recommends splenectomy as it is the treatment with the highest curative potential and an acceptable safety profile. If possible, splenectomy should be delayed to at least twelve months after diagnosis as spontaneous remission can occur in this time period. Thrombopoietin receptor (TPO-R) agonists are recommended for patients who are refractory to or relapse after splenectomy or who have a contra-indication to splenectomy irrespective of the duration of ITP. The guideline panel agrees that rituximab, azathioprine, cyclophosphamide, cyclosporine A, danazol, dapsone, mycophenolate mofetil and vincristine/vinblastine are potential treatment options, especially for patients refractory to TPO-R agonists.
(BELG J HEMATOL 2013;1:11–20)
Read moreBJH - 2013, issue BHS Abstractbook, january 2013
L. Belle , M. Binsfeld , M. Hannon , J. Caers MD, PhD, A. Briquet PhD, M. Menten , Y. Beguin MD, PhD, S. Humblet , prof. F. Baron
BJH - 2013, issue BHS Abstractbook, january 2013
M. Hannon , C. Lechanteur PhD, J. Somja MD, PhD, S. Lucas , L. Belle , F. Bruck , E. Baudoux MD, Y. Beguin MD, PhD, S. Humblet-Baron , prof. F. Baron
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