Articles

P1.13 Blocking S100A9 interactions in the Multiple Myeloma bone marrow environment reduces angiogenesis and tumor growth

BJH - volume 7, issue Abstract Book BHS, january 2016

E. Van Valckenborgh PhD, K. De Veirman , H. De Raeve MD, PhD, dr. K. Maes , E. De Bruyne , E. Menu , K. Vanderkerken PhD

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P1.18 Monoclonal B-cell lymphocytosis with a lymphoma phenotype: characterization and prognosis of a patient cohort

BJH - volume 6, issue Abstract Book BHS, january 2015

S. Vander Meeren , B. Heyrman MD, W. Renmans , K. Jochmans MD, PhD, M. Bakkus PhD, H. De Raeve MD, PhD, R. Schots MD, PhD, M. De Waele

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P.19 Clonaly related monoclonal B-cell lymphocytosis and diffuse large B-cell lymphoma in a patient treated for EBV-positive Hodgkin lymphoma

BJH - 2013, issue BHS Abstractbook, january 2013

C. Caron , A. De Becker MD, K. Fostier MD, M. De Waele , H. De Raeve MD, PhD, R. Schots MD, PhD, F. Trullemans

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Concomitant JAK2 V617F positive essential thrombocytemia and BCR-ABL1 positive chronic myeloid leukaemia masked by imatinib therapy for a gastrointestinal stromal tumour

BJH - volume 3, issue 3, september 2012

E. Del Biondo MD, H. De Raeve MD, PhD, G. Huysmans MD, K. Hendrickx MD, E. Wouters MD, P. Vandenberghe MD, PhD, P. Meeus MD

Summary

The coincidence of a Janus Kinase 2 (JAK2) V617F positive myeloproliferative neoplasm (MPN) and a BCR-ABL1 positive chronic myeloid leukaemia (CML) is rare. We present a patient whose bone marrow and peripheral blood showed typical features of essential thrombocytemia (ET). However, the normalisation of the white blood cell (WBC) count after therapy with imatinib for a gastrointestinal stromal tumour (GIST) suggests that an underlying CML was masked, as witnessed by the very low levels of BCR-ABL1 at the haematological diagnosis. The question remains if this is a case of two separate myeloid malignancies or a secondary event (BCR-ABL1 fusion) in a primary JAK2 V617F + ET.

(BELG J HEMATOL 2012:3:105–107)

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